With games such as Binary Domain and Yakuza, I really think that the Western branches should work with Japan and try to market/bring attention to the Japanese games. They obviously have potential, they just need the right push (or in BD's case, an actual one)...which is something they can learn from Atlus.
Yakuza is never going to work in the West now, SEGA tried and the west doesn't want it, in enough numbers sadly. So unless SEGA make the game take part inthe West and introduce western characters into the mix, its pointless really. BD was an amazing game , sadly letdown but poor P&R (well in had next to zero push the West), no 2 or 4 Player On-Line co-op (a massive mistake) and coming some 2 or so years too late.
Those are things that can be fixed and adressed with a sequel and imo SEGA should give it another crack. Also along with a next Gen Sonic a hope that Border Down sequel would be made for the consoles, I like to see the ST/PSO Team make their own version of Dark Souls and Online Adventure RPG for the consoles. SEGA Japan did so much to get consoles and console gamers On-Line when the tech and infrastructure and appetite for on-line gaming just wasn't there, now it is SEGA Japan should again make a massive push for On-Line gaming on the consoles.
SEGA should also make another Rally game IMO. The market for racers is at last coming back and I think there's a open market for a semi realistic fun racer like Rally