Halo 4 & Fable: Shithouse Rail-shooter for Kinect edition.
Hopefully some other stuff too, but I can't think of anything really big that's in the pipeline from them. I think MS and Sony might make mention of a new console too, now that the Wii U is around the corner, I think they'll want to follow suit.
Sony will probably have The Last of Us and Smash Bros: Playstation.
It'll be interesting to see how the Wii U turns out with Nintendo and if they have anything at all left in the tank for Vanilla Wii. Wii U controller has already undergone some changes I understand, the horrible analogue nub thingies from the 3DS have been scrapped in favour of proper analogue sticks and they've fixed the button layout a bit. Will be interesting to see what games they have to show off. My guess will be some Mario tech demo and Smash Bros.
Can't really think of much else that I'm really excited for to be honest. Would be cool if Sega announced the next Total War game, but I think Leipzig or one of those Euro events would be more likely. E3 is really a console show first and foremost.