Spock, you are the king of confusing thread titles.
Ever since the Marvel games got terrible reviews, I can't see SEGA returning to the world of superhero games. I'm certain we'll never see them given SEGA of America no longer handles console game development and SEGA Europe is content with PC RTS games.
But, if I were to pick one for fun, I'd say SEGA could make a pretty awesome Punisher beat em up or tackle another Spider-Man arcade game.