Child of Eden - Rez is one of my all time favourite games, I'm dying to play this.
Portal 2 - Everything Valve touches is pure gold. This will be no different
Duke Nukem Forever - I love Dook, he's my hero in life. Even if the game isn't very good, it's worth playing just so that you can say that you've played Duke Nukem freakin' Forever.
Marvel vs. Capcom 3 - The sequel to one of my favourite beat em ups. I'm really not sure about the art style, but if it's half as good as MVC2 it's gonna be awesome.
Skyrim - I adored Oblivion, but couldn't really get into Fallout 3 for some reason. Hopefully this will reignite my love of wondering around and killing random townsfolk.
Last Guardian - The game that I'm going to have to buy a PS3 for. SOTC and Ico are landmarks in gaming as far as I'm concerned, hopefully this can live up to it's predecessors.
Space Channel 5 Part:2 - Yeah it's a port of a game I already own, but hell, it's Space Channel 5. Ulala in HD should be worth the price of admission alone.
I refuse to get excited by any upcoming Sonic games, I've been betrayed too many times.