Tekken or Street Fighter or Soul Calibur. Nothing to do about it.
Outside of Street Fighter, all of those have been doing terribly. Even on two platforms Tekken 6 was the worst selling in the series in a long time, and Soul Calibur has drastically dropped in sales (quality too).
Not really just that, but Street Fighter's impact on the industry is now significantly less than it was last generation, or the one before. It has more to do with people just not wanting basic fighters than anything.
Virtua Fighter has proven successful before many times, it just needs new concepts to improve interest. Not really a reboot, but a new image.