This one hurts..
As someone who was always vocal about wanting Iwata out, this is certainly not what I was expecting. This is horribly depressing news and am truly sorry for his family's loss. He was my father's age and couldn't imagine losing my father at such a young age.
The only positive thing that can come out of this is that his successor may have different, more modern ideas that may be able to help shift this companies Console woes in a more successful route.
RIP Iwata, may your legacy be remembered forever.
Also, he passed on my daughters b-day