George made the claim that no in house Japanese game has sold better than Football Manager, Total War or Company of Heroes. We weren't discussing total revenue. Still, Virtua Fighter 4 sold about 500k in the first few weeks in Japan, when I imagine it was full price. Factor in revenue from the international release, EVO, merchandise and the arcades, and I imagine it scoops up a tidy sum.
It isn't an annual release like Football Manager, nor is it a spreadsheet simulator, so I highly doubt it's been as profitable a series, but I would wager if you compare VF4's revenue with, say, Football Manager 2014, Virtua Fighter made more money.